The Systems Biology Center in New York
New York, New York
The major goal of the Systems Biology Center in New York (SBCNY) is to integrate theoretical and experimental approaches for a deep mechanistic understanding of multi-scale functional organization of mammalian physiological and pathophysiological systems and how drugs (therapeutic and abusive) affect this organization. We want to understand how the effects of molecular interactions are propagated across scales of organization from cells to tissues and organs affecting physiology and pathophysiology.
We are developing and seamlessly integrating multiple modeling approaches including graph theory analysis, differential equation-based modeling and new methods that use stochastic reaction-diffusion schemes to model dynamic processes in 3D. This theoretical integration allows us to construct and analyze multi-scale models. We have developed massively parallel programs that run on supercomputers such as IBM Blue-Gene/L both for dynamic motif searches in large networks and for simulations of differential equation-based models. The theoretical studies are well integrated with multivariable experiments to profile activity changes by reverse protein arrays, transcription factor arrays and microarrays. The multivariable experiments are combined with quantitative measurements of molecular interactions and tissue level physiological measurements to constrain models and test model predictions.
To find out more about the Systems Biology Center New York, please visit www.sbcny.org.
Research Topics Currently Explored at the SBCNY
- Differential equation-based models
- Disease
- Expression profiling
- Integrative analysis of -omics data
- Protein chemistry and kinetics
- Proteomics
- Quantitative biochemistry
- Regulatory Networks
- Signal transduction
Contact for international outreach:
Ravi Iyengar, PhD, Center Director
Terry Krulwich, PhD, Director of Education and Outreach
International visitors to the SBCNY include:
Ad Ijzerman PhD, Professor, Department of Medicinal Chemistry, Leiden/Amsterdam Center for Drug Research, Leiden University, Leiden, Netherlands
Albert Goldbeter PhD, Professor, Department of Physical Chemistry and Theoretical Biology, Physical Chemistry, Université Libre de Bruxelles, Brussels, Belgium
Björn Öbrink MD, PhD, Professor, Department of Cell and Molecular Biology, Karolinska Institute, Stockholm, Sweden
Sarwar Jamal Mohammmad, a graduate student in the laboratory of Professor Kanury Rao at ICGEB (International Centre for Genetic Engineering and Biotechnology), New Delhi, India
Relevant quantitative and systems biology degree programs:
Graduate Training Program
Pharmacology and Systems Biology Multidisciplinary Training Area
Undergraduate Training Program
SBCNY Summer Undergraduate Research Program